Prof. Angeles Villanueva Oroquieta

Dr. Angeles Villanueva is a cell biologist. Her research is mainly focused on photodynamic therapy of cancer. In the last years, she has established new collaborations with research groups in the field of mag- netic nanoparticles with applications in Medicine. She has stud ied in cell cultures: i) the mechanisms of nanoparticles internalization; ii) their subcellular localization; iii) the nano- particles biocompatibility; and iv) the identification the cell death mechanism induced by heatcontrolled intracellular hyperthermia with magnetic nanoparti- cles and an alternating magnetic field.

• Medical applications of nanoparticles.
• Cell cultures. 
• Biocompatibilty of magnetic nanoparticles. 
• Mechanisms of cell death. 
• Alterations in adhesion and cytoskeletal proteins. 
• Liposomal drug delivery. 
• Evaluation in cell cultures and in vivo experimental models of new antitumor agents. 
• Signaling pathways involved in cell death.

• “Photodynamic effects on culure tumor cells. Cytoskeleton alterations and cell death mechanisms” Villanueva A. et. col In Handbook of Photochemistry and Photobiology. Vol: 4, pp: 79-117. 2003. (Ed. H. S. Nalwa). American Scientific Publisher. California, USA
• “Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments” Rello S., et col. Apoptosis 10: 201-8, 2005
• “The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells” Villanueva A., et col. Nanotechnology 20: 115103-115111, 2009